Transcription factor trapping by RNA in gene regulatory elements

Transcription factor trapping by RNA in gene regulatory elements

Transcription factors (TFs) bind specific sequences in promoter-proximal and -distal DNA elements to regulate gene transcription. RNA is transcribed from both of these DNA elements, and some DNA binding TFs bind RNA. Hence, RNA transcribed from regulatory elements may contribute to stable TF occupan...

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Main Authors: Sigova, A. A. (Author), Abraham, B. J. (Author), Ji, X. (Author), Molinie, B. (Author), Hannett, N. M. (Author), Guo, Y. E. (Author), Giallourakis, C. C. (Author), Jangi, Mohini Rohit (Contributor), Sharp, Phillip A. (Contributor), Young, Richard A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-04-27T20:02:44Z.
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