Replication Fork Progression during Re-replication Requires the DNA Damage Checkpoint and Double-Strand Break Repair

Replication Fork Progression during Re-replication Requires the DNA Damage Checkpoint and Double-Strand Break Repair

Replication origins are under tight regulation to ensure activation occurs only once per cell cycle. Origin re-firing in a single S phase leads to the generation of DNA double-strand breaks (DSBs) and activation of the DNA damage checkpoint. If the checkpoint is blocked, cells enter mitosis with par...

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Bibliographic Details
Main Authors: Barrasa, M. Inmaculada (Author), Orr-Weaver, Terry (Contributor), Alexander, Jessica Lynne (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-04-27T20:12:52Z.
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