Replication Fork Progression during Re-replication Requires the DNA Damage Checkpoint and Double-Strand Break Repair
Replication origins are under tight regulation to ensure activation occurs only once per cell cycle. Origin re-firing in a single S phase leads to the generation of DNA double-strand breaks (DSBs) and activation of the DNA damage checkpoint. If the checkpoint is blocked, cells enter mitosis with par...
Main Authors: | , , |
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Other Authors: | , |
Format: | Article |
Language: | English |
Published: |
Elsevier,
2017-04-27T20:12:52Z.
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Subjects: | |
Online Access: | Get fulltext |