SIKs control osteocyte responses to parathyroid hormone

SIKs control osteocyte responses to parathyroid hormone

Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2. Salt inducib...

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Main Authors: Wein, Marc N. (Author), Liang, Yanke (Author), Goransson, Olga (Author), Sundberg, Thomas B. (Author), Wang, Jinhua (Author), Williams, Elizabeth A. (Author), O'Meara, Maureen J. (Author), Govea, Nicolas (Author), Beqo, Belinda (Author), Nishimori, Shigeki (Author), Nagano, Kenichi (Author), Brooks, Daniel J. (Author), Martins, Janaina S. (Author), Corbin, Braden (Author), Anselmo, Anthony (Author), Sadreyev, Ruslan (Author), Wu, Joy Y. (Author), Sakamoto, Kei (Author), Foretz, Marc (Author), Baron, Roland (Author), Bouxsein, Mary L. (Author), Gardella, Thomas J. (Author), Divieti-Pajevic, Paola (Author), Gray, Nathanael S. (Author), Kronenberg, Henry M. (Author), Xavier, Ramnik Joseph (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-05-02T13:52:13Z.
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