Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes

Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes

We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes. Here, we combine these maps with new Hi-C, microscopy, and genome-editing experiments to study the physical structure of chromatin fibers, domains, and loops. We find that the observed contact domains are incon...

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Main Authors: Sanborn, Adrian L. (Author), Rao, Suhas S. P. (Author), Huang, Su-Chen (Author), Durand, Neva C. (Author), Huntley, Miriam H. (Author), Jewett, Andrew I. (Author), Bochkov, Ivan D. (Author), Chinnappan, Dharmaraj (Author), Cutkosky, Ashok (Author), Li, Jian (Author), Geeting, Kristopher P. (Author), Gnirke, Andreas (Author), Melnikov, Alexandre (Author), McKenna, Doug (Author), Stamenova, Elena K. (Author), Aiden, Erez Lieberman (Author), Lander, Eric Steven (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2017-05-04T23:04:05Z.
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