The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are fundamental questions in biology. We found that increased neutral essential amino acid (NEAA) uptake was a critical component of erythropoies...

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Main Authors: Chung, J. (Author), Bauer, D. E. (Author), Ghamari, A. (Author), Nizzi, C. P. (Author), Deck, K. M. (Author), Kingsley, P. D. (Author), Yien, Y. Y. (Author), Huston, N. C. (Author), Chen, C. (Author), Schultz, I. J. (Author), Dalton, A. J. (Author), Wittig, J. G. (Author), Palis, J. (Author), Orkin, S. H. (Author), Eisenstein, R. S. (Author), Cantor, A. B. (Author), Paw, B. H. (Author), Lodish, Harvey F (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-05-05T14:47:25Z.
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