The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability
In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are fundamental questions in biology. We found that increased neutral essential amino acid (NEAA) uptake was a critical component of erythropoies...
Main Authors: | Chung, J. (Author), Bauer, D. E. (Author), Ghamari, A. (Author), Nizzi, C. P. (Author), Deck, K. M. (Author), Kingsley, P. D. (Author), Yien, Y. Y. (Author), Huston, N. C. (Author), Chen, C. (Author), Schultz, I. J. (Author), Dalton, A. J. (Author), Wittig, J. G. (Author), Palis, J. (Author), Orkin, S. H. (Author), Eisenstein, R. S. (Author), Cantor, A. B. (Author), Paw, B. H. (Author), Lodish, Harvey F (Contributor) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor) |
Format: | Article |
Language: | English |
Published: |
American Association for the Advancement of Science (AAAS),
2017-05-05T14:47:25Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Sestrin2 is a leucine sensor for the mTORC1 pathway
by: Shen, K., et al.
Published: (2017) -
Leucine regulates autophagy via acetylation of the mTORC1 component raptor
by: Sung Min Son, et al.
Published: (2020-06-01) -
FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1.
by: Xiaochun Wu, et al.
Published: (2016-01-01) -
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
by: Saxton, Robert Andrew, et al.
Published: (2017) -
Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1
by: Asara, J.M, et al.
Published: (2022)