Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

Inflammasomes are cytosolic caspase-1-activation complexes that sense intrinsic and extrinsic danger signals, and trigger inflammatory responses and pyroptotic cell death. Homotypic interactions among Pyrin domains and caspase recruitment domains (CARDs) in inflammasome-complex components mediate ol...

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Main Authors: Lu, Alvin (Author), Li, Yang (Author), Schmidt, Florian I (Author), Yin, Qian (Author), Chen, Shuobing (Author), Fu, Tian-Min (Author), Tong, Alexander B (Author), Mao, Youdong (Author), Wu, Hao (Author), Ploegh, Hidde (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-05-05T17:52:12Z.
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