Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase (PK), and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer. To interrogate the functional requirement for PKM2 during development and tissue homeostasis, we generat...

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Bibliographic Details
Main Authors: Clish, Clary B. (Author), Bronson, Roderick T. (Author), Dayton, Talya L. (Contributor), Gocheva, Vasilena (Contributor), Miller, Kathryn (Contributor), Israelsen, William James (Contributor), Bhutkar, Arjun (Contributor), Davidson, Shawn Michael (Contributor), Luengo, Alba (Contributor), Jacks, Tyler E. (Contributor), Vander Heiden, Matthew G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2017-05-09T15:03:49Z.
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