Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevents Host Invasion of Divergent Plasmodial Species

Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevents Host Invasion of Divergent Plasmodial Species

Malaria causes nearly 1 million deaths annually. Recent emergence of multidrug resistance highlights the need to develop novel therapeutic interventions against human malaria. Given the involvement of sugar binding plasmodial proteins in host invasion, we set out to identify such proteins as targets...

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Bibliographic Details
Main Authors: Chandramohanadas, Rajesh (Author), Basappa, Rajesh (Author), Russell, Bruce (Author), Liew, Kingsley (Author), Yau, Yin Hoe (Author), Chong, Alvin (Author), Liu, Min (Author), Gunalan, Karthigayan (Author), Renia, Laurent (Author), Nosten, Francois (Author), Shochat, Susana Geifman (Author), Preiser, Peter (Author), Raman, Rahul (Contributor), Dao, Ming (Contributor), Suresh, Subra (Contributor), Sasisekharan, Ram (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor)
Format: Article
Language:English
Published: Oxford University Press, 2017-05-18T15:45:20Z.
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