All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

All-optical electrophysiology-spatially resolved simultaneous optical perturbation and measurement of membrane voltage-would open new vistas in neuroscience research. We evolved two archaerhodopsin-based voltage indicators, QuasAr1 and QuasAr2, which show improved brightness and voltage sensitivity,...

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Main Authors: Hochbaum, Daniel R (Author), Zhao, Yongxin (Author), Farhi, Samouil L (Author), Werley, Christopher A (Author), Kapoor, Vikrant (Author), Zou, Peng (Author), Kralj, Joel M (Author), Maclaurin, Dougal (Author), Smedemark-Margulies, Niklas (Author), Saulnier, Jessica L (Author), Boulting, Gabriella L (Author), Straub, Christoph (Author), Melkonian, Michael (Author), Wong, Gane Ka-Shu (Author), Harrison, D Jed (Author), Murthy, Venkatesh N (Author), Sabatini, Bernardo L (Author), Campbell, Robert E (Author), Cohen, Adam E (Author), Klapoetke, Nathan Cao (Contributor), Cho, Yongku (Contributor), Boyden, Edward (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Media Laboratory (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-05-23T15:03:37Z.
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