Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents

Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents

The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin (CDDP) embedded within a polymeric mucoadhesive CS matrix. CSM is designed...

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Bibliographic Details
Main Authors: Powell, Geralle (Author), Chen, Julie (Author), Goldberg, Manijeh Nazari (Contributor), Manzi, Aaron (Contributor), Aydin, Erkin (Contributor), Singh, Gurtej (Contributor), Khoshkenar, Payam (Contributor), Birdi, Amritpreet Kaur (Contributor), LaPorte, Brandon (Contributor), Krauskopf, Alejandro A. (Contributor), Langer, Robert S (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: ASME International, 2017-05-30T15:58:11Z.
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