A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity

A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity

CACNA1I is a candidate schizophrenia risk gene. It encodes the pore-forming human CaV3.3 α1 subunit, a subtype of voltage-gated calcium channel that contributes to T-type currents. Recently, two de novo missense variations, T797M and R1346H, of hCaV3.3 were identified in individuals with schizophren...

Full description

Bibliographic Details
Main Authors: Andrade, A. (Author), Lipscombe, D. (Author), Hope, Jennifer M. (Contributor), Allen, Alexander (Contributor), Yorgan, Valerie A (Contributor), Pan, Jennifer Q. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Architecture (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-05-31T12:57:02Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items