A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4⁺ T-Cells to Recognition by Cytotoxic T-Lymphocytes

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4⁺ T-Cells to Recognition by Cytotoxic T-Lymphocytes

Resting CD4⁺ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic effects, nor are efficiently cleared by immune effectors. Elimination of this re...

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Main Authors: O'Connor, Rachel (Author), Rimpel, Katherine (Author), Sloan, Derek D. (Author), Karel, Dan (Author), Wong, Hing C. (Author), Jeng, Emily K. (Author), Thomas, Allison S. (Author), Whitney, James B. (Author), Lim, So-Yon (Author), Kovacs, Colin (Author), Benko, Erika (Author), Karandish, Sara (Author), Huang, Szu-Han (Author), Buzon, Maria J. (Author), Lichterfeld, Mathias (Author), Irrinki, Alivelu (Author), Murry, Jeffrey P. (Author), Tsai, Angela (Author), Yu, Helen (Author), Geleziunas, Romas (Author), Trocha, Alicja (Author), Ostrowski, Mario A. (Author), Walker, Bruce D. (Author), Jones, Richard Bradley (Contributor), Mueller, Stefanie (Contributor), Irvine, Darrell J (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2017-05-31T13:45:27Z.
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