A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production

A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production

We present an integrated microfluidic bioreactor for fully continuous perfusion cultivation of suspended microbial cell cultures. This system allowed continuous and stable heterologous protein expression by sustaining the cultivation of Pichia pastoris over 11 days. This technical capability also al...

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Bibliographic Details
Main Authors: Lee, Kevin S. (Author), Lee, Harry L. T. (Author), Mozdzierz, Nicholas Joseph (Contributor), Love, Kerry R. (Contributor), Shah, Kartik A (Contributor), Ram, Rajeev J (Contributor), Love, John C (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Biomedical Innovation (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Research Laboratory of Electronics (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry, The, 2017-05-31T14:09:27Z.
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