Virtually Instantaneous, Room-Temperature [[superscript 11]C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes

A new radiosynthetic protocol for the preparation of [[superscript 11]C]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L·Pd(Ar)X complexes (L = biaryl phosphine) with [[superscript 11]C]HCN. The strategy is operationally simple, exhibits a remarkab...

Full description

Bibliographic Details
Main Authors: Placzek, Michael S. (Author), Hooker, Jacob M. (Author), Lee, Hong Geun (Contributor), Milner, Phillip John (Contributor), Buchwald, Stephen Leffler (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2017-06-01T20:21:38Z.
Subjects:
Online Access:Get fulltext