Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

It is increasingly appreciated that oncogenic transformation alters cellular metabolism to facilitate cell proliferation, but less is known about the metabolic changes that promote cancer cell aggressiveness. Here, we analyzed metabolic gene expression in cancer cell lines and found that a set of hi...

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Main Authors: Freinkman, Elizaveta (Author), Comb, William C (Author), Cantor, Jason R (Author), Tam, Wai Leong (Author), Thiru, Prathapan (Author), Kanarek, Naama (Author), Bierie, Brian (Author), Shaul, Yoav (Contributor), Kim, Dohoon (Contributor), Chen, Walter W. (Contributor), Possemato, Richard (Contributor), Reinhardt, Ferenc (Contributor), Weinberg, Robert A (Contributor), Yaffe, Michael B (Contributor), Sabatini, David (Contributor), Pacold, Michael Edward (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Ludwig Center for Molecular Oncology (Massachusetts Institute of Technology) (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Pacold, Michael E (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-06-02T17:24:08Z.
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