Mutations that Allow SIR2 Orthologs to Function in a NAD⁺ -Depleted Environment
Sirtuin enzymes depend on NAD⁺ to catalyze protein deacetylation. Therefore, the lowering of NAD⁺ during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic dom...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier,
2017-06-13T17:47:27Z.
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| Subjects: | |
| Online Access: | Get fulltext |