Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

Antibiotic resistance arising via chromosomal mutations is typically specific to a particular antibiotic or class of antibiotics. We have identified mutations in genes encoding ribosomal components in Mycobacterium smegmatis that confer resistance to several structurally and mechanistically unrelate...

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Main Authors: Gomez, James E (Author), Kaufmann-Malaga, Benjamin B (Author), Wivagg, Carl N (Author), Kim, Peter B (Author), Silvis, Melanie R (Author), Renedo, Nikolai (Author), Ioerger, Thomas R (Author), Ahmad, Rushdy (Author), Livny, Jonathan (Author), Fishbein, Skye (Author), Hung, Deborah T (Author), Carr, Steven A (Contributor)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd., 2017-06-14T17:43:07Z.
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