A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

The eight-subunit T cell receptor (TCR)-CD3 complex is the primary determinant for T cell fate decisions. Yet how it relays ligand-specific information across the cell membrane for conversion to chemical signals remains unresolved. We hypothesized that TCR engagement triggers a change in the spatial...

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Bibliographic Details
Main Authors: Lee, Mark S (Author), Glassman, Caleb R (Author), Deshpande, Neha R (Author), Badgandi, Hemant B (Author), Parrish, Heather L (Author), Kuhns, Michael S (Author), Uttamapinant, Chayasith (Contributor), Stawski, Philipp Sebastian (Contributor), Ting, Alice Y (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-06-26T18:56:27Z.
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