CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

Chronic hepatitis B virus (HBV) infection is prevalent, deadly, and seldom cured due to the persistence of viral episomal DNA (cccDNA) in infected cells. Newly developed genome engineering tools may offer the ability to directly cleave viral DNA, thereby promoting viral clearance. Here, we show that...

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Main Authors: Shlomai, Amir (Author), Michailidis, Eleftherios (Author), Bhatta, Ankit (Author), Rice, Charles M. (Author), Ramanan, Vyas (Contributor), Cox, David Benjamin Turitz (Contributor), Scott, David Arthur (Contributor), Zhang, Feng (Contributor), Bhatia, Sangeeta N (Contributor), Schwartz, Robert E. (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Schwartz, Robert E (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-06-28T13:11:04Z.
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