Proteotoxic Stress Induces a Cell-Cycle Arrest by Stimulating Lon to Degrade the Replication Initiator DnaA

The decision to initiate DNA replication is a critical step in the cell cycle of all organisms. Cells often delay replication in the face of stressful conditions, but the underlying mechanisms remain incompletely defined. Here, we demonstrate in Caulobacter crescentus that proteotoxic stress induces...

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Bibliographic Details
Main Authors: Liu, Jing (Author), Jonas, Kristina (Contributor), Laub, Michael T (Contributor), Chien, Peter 1976- (Author)
Other Authors: Howard Hughes Medical Institute (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-06-29T16:51:19Z.
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