SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia

SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia

Cooperative dependencies between mutant oncoproteins and wild-type proteins are critical in cancer pathogenesis and therapy resistance. Although spleen tyrosine kinase (SYK) has been implicated in hematologic malignancies, it is rarely mutated. We used kinase activity profiling to identify collabora...

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Main Authors: Puissant, Alexandre (Author), Alexe, Gabriela (Author), Pikman, Yana (Author), Bassil, Christopher F (Author), Mehta, Swapnil (Author), Du, Jinyan (Author), Kazi, Julhash U (Author), Luciano, Frédéric (Author), Rönnstrand, Lars (Author), Kung, Andrew L (Author), Aster, Jon C (Author), Galinsky, Ilene (Author), Stone, Richard M (Author), DeAngelo, Daniel J (Author), Stegmaier, Kimberly (Author), Fenouille, Nina (Contributor), Hemann, Michael (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-06-30T20:19:42Z.
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