Necroptosis-Inducing Rhenium(V) Oxo Complexes

Necroptosis-Inducing Rhenium(V) Oxo Complexes

Rhenium(V) oxo complexes of general formula [ReO(OMe)(N^N)Cl₂], where N^N = 4,7-diphenyl-1,10-phenanthroline, 1, or 3,4,7,8-tetramethyl-1,10-phenanthroline, 2, effectively kill cancer cells by triggering necroptosis, a non-apoptotic form of cell death. Both complexes evoke necrosome (RIP1-RIP3)-depe...

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Main Authors: Suntharalingam, Kogularamanan (Contributor), Awuah, Samuel (Contributor), Bruno, Peter Michael (Contributor), Johnstone, Timothy (Contributor), Wang, Fang (Contributor), Lin, Wei (Contributor), Zheng, Yaorong (Contributor), Page, Julia E. (Contributor), Hemann, Michael (Contributor), Lippard, Stephen J. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2017-07-03T13:47:29Z.
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