Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for either Tet1 or Tet2 are viable, raising the question of whether these enzymes have overlapping roles in development. Here we have generated Tet1 and Tet2 do...

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Bibliographic Details
Main Authors: Dawlaty, Meelad M (Author), Breiling, Achim (Author), Le, Thuc (Author), Raddatz, Günter (Author), Barrasa, M. Inmaculada (Author), Cheng, Albert W (Author), Gao, Qing (Author), Powell, Benjamin E (Author), Li, Zhe (Author), Xu, Mingjiang (Author), Faull, Kym F (Author), Lyko, Frank (Author), Jaenisch, Rudolf (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-07-06T18:29:48Z.
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