Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling malignant, immune, stromal, and endothelial cells. Malignant cells within the same tumor displayed transcriptional het...

Full description

Bibliographic Details
Main Authors: Tirosh, I. (Author), Izar, B. (Author), Treacy, D. (Author), Trombetta, J. J. (Author), Rotem, A. (Author), Rodman, C. (Author), Lian, C. (Author), Murphy, G. (Author), Fallahi-Sichani, M. (Author), Dutton-Regester, K. (Author), Lin, J.-R (Author), Cohen, O. (Author), Shah, P. (Author), Lu, D. (Author), Villani, A.-C (Author), Andreev, A. Y. (Author), Van Allen, E. M. (Author), Bertagnolli, M. (Author), Sorger, P. K. (Author), Sullivan, R. J. (Author), Flaherty, K. T. (Author), Frederick, D. T. (Author), Jane-Valbuena, J. (Author), Rozenblatt-Rosen, O. (Author), Prakadan, Sanjay (Contributor), Wadsworth, Marc Havens (Contributor), Genshaft, Alex S. (Contributor), Hughes, Travis K. (Contributor), Ziegler, Carly (Contributor), Kazer, Samuel Weisgurt (Contributor), Gaillard de Saint Germain, Alethe (Contributor), Kolb, Kellie Elizabeth (Contributor), Johannessen, Cory M. (Contributor), Yoon, Clifford H. (Contributor), Shalek, Alexander K (Contributor), Regev, Aviv (Contributor), Garraway, Levi A. (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Garraway, Levi (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-07-07T19:22:03Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items