Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Background A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues. We investigated aggrecan proteolysis patterns in cartilage explants usin...

Full description

Bibliographic Details
Main Authors: Swärd, Per (Author), Hansson, Maria (Author), Lohmander, L. S (Author), Struglics, André (Author), Lohmander, L. Stefan (Author), Grodzinsky, Alan J. (Author), Wang, Yang (Contributor), Grodzinsky, Alan J (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd, 2017-07-10T15:17:16Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items