A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in combating malaria requires development of new, easy to administer drug combinations with broad-ranging...

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Main Authors: Phillips, M. A. (Author), Lotharius, J. (Author), Marsh, K. (Author), White, J. (Author), Dayan, A. (Author), White, K. L. (Author), Njoroge, J. W. (Author), El Mazouni, F. (Author), Lao, Y. (Author), Kokkonda, S. (Author), Tomchick, D. R. (Author), Deng, X. (Author), Laird, T. (Author), Ng, C. L. (Author), Fidock, D. A. (Author), Wittlin, S. (Author), Lafuente-Monasterio, M. (Author), Benito, F. J. G. (Author), Alonso, L. M. S. (Author), Martinez, M. S. (Author), Jimenez-Diaz, M. B. (Author), Bazaga, S. F. (Author), Angulo-Barturen, I. (Author), Haselden, J. N. (Author), Louttit, J. (Author), Cui, Y. (Author), Sridhar, A. (Author), Zeeman, A.-M (Author), Kocken, C. (Author), Sauerwein, R. (Author), Dechering, K. (Author), Avery, V. M. (Author), Duffy, S. (Author), Delves, M. (Author), Sinden, R. (Author), Ruecker, A. (Author), Wickham, K. S. (Author), Rochford, R. (Author), Gahagen, J. (Author), Iyer, L. (Author), Riccio, E. (Author), Mirsalis, J. (Author), Bathhurst, I. (Author), Rueckle, T. (Author), Ding, X. (Author), Campo, B. (Author), Leroy, D. (Author), Rogers, M. J. (Author), Rathod, P. K. (Author), Burrows, J. N. (Author), Charman, S. A. (Author), Bhatia, Sangeeta N (Contributor), March-Riera, Sandra (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-07-19T14:40:56Z.
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