A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

Summary: Transcription activator-like effector nucleases (TALENs) are a new class of engineered nucleases that are easier to design to cleave at desired sites in a genome than previous types of nucleases. We report here the use of TALENs to rapidly and efficiently generate mutant alleles of 15 genes...

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Main Authors: Ding, Qiurong (Author), Lee, Youn-Kyoung (Author), Schaefer, Esperance A.K (Author), Peters, Derek T (Author), Veres, Adrian (Author), Kim, Kevin (Author), Kuperwasser, Nicolas (Author), Motola, Daniel L (Author), Meissner, Torsten B (Author), Hendriks, William T (Author), Trevisan, Marta (Author), Gupta, Rajat M (Author), Moisan, Annie (Author), Banks, Eric (Author), Friesen, Max (Author), Schinzel, Robert T (Author), Xia, Fang (Author), Tang, Alexander (Author), Xia, Yulei (Author), Figueroa, Emmanuel (Author), Wann, Amy (Author), Ahfeldt, Tim (Author), Daheron, Laurence (Author), Zhang, Feng (Contributor), Rubin, Lee L (Author), Peng, Lee F (Author), Chung, Raymond T (Author), Musunuru, Kiran (Author), Cowan, Chad A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2017-07-25T16:35:35Z.
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