Improved vectors and genome-wide libraries for CRISPR screening

Improved vectors and genome-wide libraries for CRISPR screening

To the Editor: Genome-wide, targeted loss-of-function pooled screens using the clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated nuclease Cas9 in human and mouse cells provide an alternative screening system to RNA interference (RNAi)1, 2, 3, 4. Previously, we used a ge...

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Bibliographic Details
Main Authors: Sanjana, Neville E (Contributor), Shalem, Ophir (Contributor), Zhang, Feng (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2017-07-26T15:17:59Z.
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