Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

Neuronal activity causes the rapid expression of immediate early genes that are crucial for experience-driven changes to synapses, learning, and memory. Here, using both molecular and genome-wide next-generation sequencing methods, we report that neuronal activity stimulation triggers the formation...

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Main Authors: Madabhushi, Ram (Contributor), Pfenning, Andreas R. (Contributor), Gao, Fan (Contributor), Pan, Ling (Contributor), Yamakawa, Satoko (Contributor), Seo, Jinsoo (Contributor), Rueda IV, Richard (Contributor), Phan, Trongha (Contributor), Yamakawa, Hidekuni (Contributor), Pao, Ping-Chieh (Contributor), Stott, Ryan T (Contributor), Gjoneska, Elizabeta (Contributor), Nott, Alexander (Contributor), Cho, Sukhee (Contributor), Kellis, Manolis (Contributor), Tsai, Li-Huei (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-08-30T20:01:55Z.
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