Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions

Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions

Massively parallel reporter assays (MPRAs) enable nucleotide-resolution dissection of transcriptional regulatory regions, such as enhancers, but only few regions at a time. Here we present a combined experimental and computational approach, Systematic high-resolution activation and repression profil...

Full description

Bibliographic Details
Main Authors: Ernst, Jason (Author), Melnikov, Alexandre (Contributor), Zhang, Xiaolan (Contributor), Wang, Li (Contributor), Rogov, Peter L (Contributor), Mikkelsen, Tarjei (Contributor), Kellis, Manolis (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-09-01T14:17:57Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items