Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

Genetic screens are powerful tools for identifying genes responsible for diverse phenotypes. Here we describe a genome-wide CRISPR/Cas9-mediated loss-of-function screen in tumor growth and metastasis. We mutagenized a non-metastatic mouse cancer cell line using a genome-scale library with 67,405 sin...

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Main Authors: Lee, Kyungheon (Author), Song, Jun (Author), Weissleder, Ralph (Author), Lee, Hakho (Author), Chen, Sidi (Contributor), Sanjana, Neville E (Contributor), Zheng, Kaijie (Contributor), Shalem, Ophir (Contributor), Shi, Xi (Contributor), Scott, David Arthur (Contributor), Pan, Jennifer Q. (Contributor), Zhang, Feng (Contributor), Sharp, Phillip A. (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-09-13T15:05:14Z.
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