Calibrating genomic and allelic coverage bias in single-cell sequencing

Calibrating genomic and allelic coverage bias in single-cell sequencing

Artifacts introduced in whole-genome amplification (WGA) make it difficult to derive accurate genomic information from single-cell genomes and require different analytical strategies from bulk genome analysis. Here, we describe statistical methods to quantitatively assess the amplification bias resu...

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Bibliographic Details
Main Authors: Zhang, Cheng-Zhong (Author), Francis, Joshua (Author), Cornils, Hauke (Author), Jung, Joonil (Author), Maire, Cecile (Author), Ligon, Keith L. (Author), Meyerson, Matthew (Author), Adalsteinsson, Viktor A. (Contributor), Love, John C (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-10-02T14:11:45Z.
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