Synergistic interactions with PI3K inhibition that induce apoptosis

Synergistic interactions with PI3K inhibition that induce apoptosis

Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for genes that are required for the survival of PI3K muta...

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Main Authors: Zwang, Yaara (Author), Chen, Casandra (Author), Rinne, Mikael L (Author), Doench, John G (Author), Piccioni, Federica (Author), Tan, Li (Author), Huang, Hai-Tsang (Author), Wang, Jinhua (Author), Ham, Young Jin (Author), O'Connell, Joyce (Author), Bhola, Patrick (Author), Doshi, Mihir (Author), Whitman, Matthew (Author), Letai, Anthony (Author), Root, David E (Author), Gray, Nathanael (Author), Hahn, William C (Author), Jonas, Oliver H. (Contributor), Langer, Robert S (Contributor), Cima, Michael J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Cima, Michael J (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd, 2017-10-04T19:47:59Z.
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