Evidence of reduced recombination rate in human regulatory domains

Evidence of reduced recombination rate in human regulatory domains

Background Recombination rate is non-uniformly distributed across the human genome. The variation of recombination rate at both fine and large scales cannot be fully explained by DNA sequences alone. Epigenetic factors, particularly DNA methylation, have recently been proposed to influence the varia...

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Main Authors: Ernst, Jason (Author), Liu, Yaping (Contributor), Sarkar, Abhishek Kulshreshtha (Contributor), Kheradpour, Pouya (Contributor), Kellis, Manolis (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: BioMed Central, 2017-10-26T19:22:08Z.
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