Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro

Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro

Major neuropsychiatric disorders are genetically complex but share overlapping etiology. Mice mutant for rare, highly penetrant risk variants can be useful in dissecting the molecular mechanisms involved. The gene disrupted in schizophrenia 1 (DISC1) has been associated with increased risk for neuro...

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Main Authors: Molinos, I (Author), Petit, E (Author), Bellini, S (Author), O'Tuathaigh, C (Author), Schorova, L (Author), Mitchell, K J (Author), Waddington, J (Author), Gill, M (Author), Corvin, A P (Author), Tropea, Daniela (Contributor), Nagakura, Ikue (Contributor), Sur, Mriganka (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-12-05T19:27:17Z.
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