Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

Microglia, the tissue-resident macrophages in the brain, are damage sensors that react to nearly any perturbation, including neurodegenerative diseases such as Alzheimer's disease (AD). Here, using single-cell RNA sequencing, we determined the transcriptome of more than 1,600 individual microgl...

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Main Authors: Hemberg, Martin (Author), De Jager, Philip L. (Author), Ransohoff, Richard M. (Author), Mathys, Hansruedi (Contributor), Adaikkan, Chinnakkaruppan (Contributor), Gao, Fan (Contributor), Young, Jennie Zin-Ney (Contributor), Manet, Elodie (Contributor), Regev, Aviv (Contributor), Tsai, Li-Huei (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-12-11T14:36:13Z.
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