The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

The histone deacetylase HDAC2, which negatively regulates synaptic gene expression and neuronal plasticity, is upregulated in Alzheimer's disease (AD) patients and mouse models. Therapeutics targeting HDAC2 hold promise for ameliorating AD-related cognitive impairment; however, attempts to gene...

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Bibliographic Details
Main Authors: Yamakawa, Hidekuni (Contributor), Cheng, Jemmie (Contributor), Penney, Jay (Contributor), Gao, Fan (Contributor), Rueda IV, Richard (Contributor), Wang, Jun (Contributor), Yamakawa, Satoko (Contributor), Kritskiy, Oleg (Contributor), Gjoneska, Elizabeta (Contributor), Tsai, Li-Huei (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-12-11T14:42:26Z.
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