Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2 R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood. We found that neuronal deletion...

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Main Authors: Zhang, Feiran (Author), Jin, Peng (Author), Nott, Alexander (Contributor), Cheng, Jemmie (Contributor), Gao, Fan (Contributor), Lin, Yuan-Ta (Contributor), Gjoneska, Elizabeta (Contributor), Ko, Tak (Contributor), Minhas, Paras S (Contributor), Zamudio Montes de Oca, Alicia (Contributor), Meng, Jia (Contributor), Tsai, Li-Huei (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-12-11T15:39:19Z.
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