Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin

Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin

A short half-life in the circulation limits the application of therapeutics such as single-domain antibodies (VHHs). We utilize red blood cells to prolong the circulatory half-life of VHHs. Here we present VHHs against botulinum neurotoxin A (BoNT/A) on the surface of red blood cells by expressing c...

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Bibliographic Details
Main Authors: Huang, Nai-Jia (Author), Mukherjee, Jean (Author), Zhang, Sicai (Author), Shoemaker, Charles B. (Author), Pishesha, Novalia (Contributor), Deshycka, Rhogerry (Contributor), Sudaryo, Valentino (Contributor), Lodish, Harvey F (Contributor), Dong, Min 1968- (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-12-12T14:46:21Z.
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