A structural and mechanistic study of π-clamp-mediated cysteine perfluoroarylation

A structural and mechanistic study of π-clamp-mediated cysteine perfluoroarylation

Natural enzymes use local environments to tune the reactivity of amino acid side chains. In searching for small peptides with similar properties, we discovered a four-residue π-clamp motif (Phe-Cys-Pro-Phe) for regio- and chemoselective arylation of cysteine in ribosomally produced proteins. Here we...

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Bibliographic Details
Main Authors: Dai, Peng (Contributor), Williams, Jonathan Kyle (Contributor), Zhang, Chi (Contributor), Welborn, Matthew Gregory (Contributor), Shepherd, James J (Contributor), Zhu, Tianyu (Contributor), Van Voorhis, Troy (Contributor), Hong, Mei (Contributor), Pentelute, Bradley L. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-12-12T15:43:12Z.
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