Transcription control by the ENL YEATS domain in acute leukaemia

Transcription control by the ENL YEATS domain in acute leukaemia

Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical outcome. The preferential involvement of chromatin-associated factors as MLL fusion partners belies a dependency on transcription control. Despite re...

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Main Authors: Erb, Michael A. (Author), Scott, Thomas G. (Author), Li, Bin E. (Author), Xie, Huafeng (Author), Paulk, Joshiawa (Author), Seo, Hyuk-Soo (Author), Souza, Amanda (Author), Roberts, Justin M. (Author), Dastjerdi, Shiva (Author), Buckley, Dennis L. (Author), Nabet, Behnam (Author), Zeid, Rhamy (Author), Offei-Addo, Nana K. (Author), Dhe-Paganon, Sirano (Author), Orkin, Stuart H. (Author), Winter, Georg E. (Author), Bradner, James E. (Author), Sanjana, Neville E (Contributor), Shalem, Ophir (Contributor), Zhang, Feng (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-12-14T14:13:56Z.
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