Nucleic acid detection with CRISPR-Cas13a/C2c2

Nucleic acid detection with CRISPR-Cas13a/C2c2

Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas13a (previously known as C2c2) exhibits a "collater...

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Main Authors: Lee, Jeong Wook (Author), Essletzbichler, Patrick (Author), Verdine, Vanessa (Author), Donghia, Nina (Author), Freije, Catherine A. (Author), Myhrvold, Cameron (Author), Bhattacharyya, Roby P. (Author), Livny, Jonathan (Author), Koonin, Eugene V. (Author), Pardis, C. Sabeti (Author), Gootenberg, Jonathan S (Contributor), Dy, Aaron James (Contributor), Joung, Julia (Contributor), Daringer, Nichole Marie (Contributor), Regev, Aviv (Contributor), Hung, Deborah T (Contributor), Collins, James J. (Contributor), Zhang, Feng (Contributor), Abudayyeh, Omar O. (Author)
Other Authors: Institute for Medical Engineering and Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Abudayyeh, Omar Osama (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-12-14T14:34:12Z.
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