Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

Aiming towards the development of novel nootropic therapeutics to address the cognitive impairment common to a range of brain disorders, we set out to develop highly selective small molecule inhibitors of HDAC2, a chromatin modifying histone deacetylase implicated in memory formation and synaptic pl...

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Main Authors: Wagner, F. F. (Author), Zhang, Y.-L (Author), Fass, D. M. (Author), Gale, J. P. (Author), Weïwer, M. (Author), McCarren, P. (Author), Fisher, S. L. (Author), Kaya, T. (Author), Zhao, W.-N (Author), Reis, S. A. (Author), Hennig, K. M. (Author), Thomas, M. (Author), Lemercier, B. C. (Author), Lewis, M. C. (Author), Moyer, M. P. (Author), Scolnick, E. (Author), Haggarty, S. J. (Author), Holson, E. B. (Author), Joseph, Nadine (Contributor), Guan, Jisong (Contributor), Tsai, Li-Huei (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry (RSC), 2017-12-14T14:38:26Z.
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