Copper-catalyzed asymmetric addition of olefin-derived nucleophiles to ketones

Enantioenriched alcohols found in an array of bioactive natural products and pharmaceutical agents are often synthesized by asymmetric nucleophilic addition to carbonyls. However, this approach generally shows limited functional-group compatibility, requiring the use of preformed organometallic reag...

Full description

Bibliographic Details
Main Authors: Lu, G. (Author), Liu, P. (Author), Yang, Yang (Contributor), Perry, Ian (Contributor), Buchwald, Stephen Leffler (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2018-01-10T15:40:48Z.
Subjects:
Online Access:Get fulltext