Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection

Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection

The contribution of pre-mRNA processing mechanisms to the regulation of immune responses remains poorly studied despite emerging examples of their role as regulators of immune defenses. We sought to investigate the role of mRNA processing in the cellular responses of human macrophages to live bacter...

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Main Authors: Baharian, Golshid (Author), Pagé Sabourin, Ariane (Author), Brinkworth, Jessica F. (Author), Nédélec, Yohann (Author), Foley, Joseph W. (Author), Grenier, Jean-Christophe (Author), Siddle, Katherine J. (Author), Dumaine, Anne (Author), Yotova, Vania (Author), Johnson, Zachary P. (Author), Lanford, Robert E. (Author), Barreiro, Luis B. (Author), Pai, Athma A. (Contributor), Burge, Christopher B (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Public Library of Science (PLoS), 2018-01-19T20:55:09Z.
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