Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival

Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival

Organisms must execute metabolic defenses to survive nutrient deprivation. We performed a genome-wide RNAi screen in Caenorhabditis elegans to identify fat regulatory genes indispensable for starvation resistance. Here, we show that opposing proteostasis pathways are principal determinants of starva...

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Bibliographic Details
Main Authors: Webster, Christopher M. (Author), Pino, Elizabeth C. (Author), Wu, Lianfeng (Author), Zhou, Ben (Author), Cedillo, Lucydalila (Author), Kacergis, Michael C. (Author), Curran, Sean P. (Author), Soukas, Alexander A. (Author), Carr, Christopher E (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-01-22T20:43:41Z.
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