Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors

Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors

Metal-free magnetic resonance imaging (MRI) agents could overcome the established toxicity associated with metal-based agents in some patient populations and enable new modes of functional MRI in vivo. Herein, we report nitroxide-functionalized brush-arm star polymer organic radical contrast agents...

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Main Authors: Paletta, Joseph T. (Author), Zhang, Hui (Author), Boska, Michael D. (Author), Ottaviani, M. Francesca (Author), Rajca, Andrzej (Author), Nguyen, Hung VanThanh (Contributor), Chen, Qixian (Contributor), Harvey, Peter (Contributor), Jiang, Yivan (Contributor), Jasanoff, Alan Pradip (Contributor), Johnson, Jeremiah A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Laboratory for Nuclear Science (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2018-01-29T18:42:35Z.
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