A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers

A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers

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BACKGROUND: Human immunity relies on the coordinated responses of many cellular subsets and functional states. Inter-individual variations in cellular composition and communication could thus potentially alter host protection. Here, we explore this hypothesis by applying single-cell RNA-sequencing t...

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Bibliographic Details
Main Authors: Martin-Gayo, Enrique (Author), Cole, Michael B. (Author), Ouyang, Zhengyu (Author), Cronin, Jacqueline (Author), Lichterfeld, Mathias (Author), Walker, Bruce D. (Author), Yosef, Nir (Author), Yu, Xu G. (Author), Kolb, Kellie Elizabeth (Contributor), Kazer, Samuel Weisgurt (Contributor), Ordovas-Montanes, Jose Manuel (Contributor), Shalek, Alexander K (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Biomed Central Ltd, 2018-02-05T16:47:33Z.
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